So I manufacture cycling products from Taiwan + China, importing to US... he's paying 152% tariffs, on the cost price of the product. Previously would have been like 7% base, with maybe a 20% trade war tarriff added on.
So for back of napkin: $10 widget, selling for eg $40.
No kidding. It blows my mind how bad e-commerce is. And how expensive it is. I had to accept that no payment processor would ever be ideal, no cost structure would ever make sense, I’d have to relinquish access to my own money to a degree, etc. I thought it would be better by 2025 but it’s the worst part of the business I’ve worked on so far, haha.
Yes but that's not the full story... .It's true that the odds of dying from anaphylaxis are low, IF treated in time.
The sad thing is that the vast majority of all deaths from allergic reactions are preventable.
Things like not acting immediately and injecting Epipen in the first few minutes, not following up with a 2nd shot if no improvement in 15min. Having expired pens. Kids grow, and need larger pens. Teacher panics and uses pen upside down. Kids try foods as a teen or when they leave home as they "used to be allergic"
As the parent of an Parent of anaphylactic 7 year old - the fear is real. Low odds, but catastrophic outcome.
We are lucky that my partner is a nurse and we are knowledgable and manage places we go, but daycare, schools, birthday situations etc are a worry
My friend's son went into anaphylaxis while out with his girlfriend, and even though she carried a spare pen, the needle bent when it hit a seam in his pants, rendering it unusable.
She called sobbing that she'd killed him, but someone had an expired pen, and he ended up okay after getting to the hospital. Still, you never know if it could be the one.
Sample size n=1, but my dad was on the research or clinical trial of this exact treatment in Sydney, it worked for his prostate cancer, he's still clear from PSA tests (and possibly had biopsy also. No side effects.
Previously he'd had the radioactive beads treatment which failed, the only other option was removal. Both these options have potentially unpleasant side effects.
Happy to ask him questions if anyone wants to know more
Would you be interested in chatting more about the whole experience? breck@cancerdb.com or 1-808-727-1111
I've been in Cancer Research for 5 years and am now starting my own idea to help (utilizing my background in software engineering and data science): CancerDB.com a public domain ad-free knowledge graph. The idea is to get a core group of researchers collating all the data into one place that's accessible by both patients, families, caregivers, and researchers.
"After a full workup to ensure that our patients are suitable for the program they then undergo a day surgery procedure which takes between 40 and 60 minutes. Depending on the extent of the cancer this may simply ablate the lesion, a quarter of the prostate or a half of the prostate. No prostate cancer cells are resistant to this treatment. Large areas can be treated with minimal side effects.
After the treatment patients stay in the day surgery unit for two to four hours and they are discharged home with a Foley catheter in place. Postoperatively pain is minimal and patients are discharged with tablets for mild pain, moderate pain, bladder spasms and relaxation of the prostate and antibiotics as required.
On day 2 a limited multiparametric MRI is performed. The Foley catheter is left in for two to five days depending on the extent of the treatment."
My father had an aggressive form of prostate cancer that required removal. He was put under at a hospital. The surgery wasn’t very long and the procedure wasn’t too invasive.
Recovery wasn’t so bad but you have a catheter for a bit. Cancer drugs and all but no hair loss. IIRC, he was very low energy. He’s been cancer free for over a decade.
There’s a chance you can lose the capability to get an erection so you’ll want a good surgeon (I did not discuss this with my dad). Another person I knew had to wear a small pad because he could have a small amount of urine dribble. He said he could pee like a horse and it was much easier post op.
May I ask how this was discovered in your dad's case? I feel like prostate cancer is the single most dangerous cancer for men in the late 30s, 40s, and 50s. So it's a subject I'm trying to pay attention to.
He had a change in PSA levels in his blood - it's a good idea to get your bloods checked annually so you can pick up any changes, as PSA levels vary a lot person to person.
Also gan get "the finger" to see if you have an enlarged prostate.
I think as far as cancers go, prostate is one of the better ones to get, not normally aggressive, you'll probably die before it kills you.
No way, colorectal and lung (even if you're a non-smoker, worse prognosis) are both relatively very common and will kill you quickly.
We're seeing a lot of early presentations in both contributing to the lower screening start by the USPTF, evidence still coming in on lung and what to do.
I was diagnosed with prostate cancer when I was about 57. I had had somewhat regular "finger up the butt" exams prior to that, since I was about 45, which were all negative. Then a PSA blood test test came back positive and I then had a biopsy done (no fun, trust me). Because I was still in my 50's I needed to do something beyond just continuing to monitor it. Between radiation treatment and a prostatectomy I chose the latter. Eight years or so later my PSA tests are still negative, knock on wood. Lesson learned, I think, is to get a simple PSA blood test done regularly once you've reached a certain age.
I don't think you can conclude that from one patient, that's not how medicine works.
Whether to actively surveil vs treat depends on individual patient characteristics and grade (generally Gleason 7+) and the fact that you didn't have a complication does not mean they're not sufficiently high. On a population level analysis the evidence clearly support that there is no improved mortality with prostate cancer screening.
So for back of napkin: $10 widget, selling for eg $40.
NORMALLY Product: $10, Shipping, storage etc: $10, Duties: $0.70, Marketing $10, Sale price: $40, Profit: $10
TRADE WAR Product: $10, Shipping, storage etc: $10, Duties: $15, Marketing $10, Sale price: $40, Profit: -$5
So to make even 15% profit, the price needs to increase from $40 to ~$52
So companies are either winding up and ditching their inventory in China (lose less), or if they can prices are going up 20+%. Inflation here we come
At that price they be losing a significant amount on this.
UPS has already laid off 20,000 people. There is about to be a tsunami of businesses winding up unfortunately (us included).