> a database that predicts the effects of every possible single nucleotide variant in the human genome. We used the AlphaGenome AI model to pre-calculate the regulatory impact of all 9 billion single-letter genetic changes, resulting in a massive, 1-petabyte dataset.
This is for a database, no? While Borzoi is a model?
> Here, we introduce Borzoi, a model that learns to predict cell-type-specific and tissue-specific RNA-seq coverage from DNA sequence.
This type of model, of which there are many, either directly releases their results as a precomputed database right away, or others release that database, or the method gets ignored.
Check out VIPdb for the broad category of methods/databases
These are predictors for "pathogenicity". Which is the vague concept of "does it cause genetic disease in humans" where "disease" itself is defined as the broad set of things that "brings patients into the doctor to figure out what's wrong."
The "regulatory impact" part of this is what differs from other predictors, in that it predicts the internal states as measured by several different assays, such as transcription regulating proteins are bound where in the genome, etc. Those predictions may or may not be usefel to people trying to reason about things going on in the cell, but my guess is that it's not going to get much use my molecular biologists, because the way the paper was described is pretty bad, and there are no experimental results I saw towards validating that.
But then, I'm not super interested in this paper. It's my field, but if there's something interesting I'm sure I'll hear about it from colleagues. Google is a fantastic advertising company that sometimes also does a bit of science, but this PR push is just an advertisement. A standard work-a-day paper gets covered as if it were ground breaking, and it will get enough eyes that I feel like I can safely ignore it until somebody in the field points out something interesting.
> Don’t submit apps that are indistinguishable from what's already widely available. Opportunistically creating variants of existing app categories or popular apps degrades App Store discovery, reduces overall app quality, and harms both users and developers. Certain kinds of apps, such as dating, flashlight, sound effects, wallpaper, simple timers, and fortune telling, are well established on the App Store and we will not accept new submissions unless they offer a meaningfully different or improved experience.
It is more like you wanting to build a bed out of wood so you hire a carpenter and watch them and ask questions about every step and maybe help a bit at the end.
After sawing off his arm while assembling an barstool he also gives advice about assembling rocket engines without any loss in confidence. Good old uncle Vinny always there when you need him.
A website for a meetup I host including a store. It was a 30min thing and amazing. A web app to track my contact lens usage. An android app for my gym routine. A web app to try drum patterns
That is exactly my point: there easily could be, but there isn't. Based on how many commenters on HN and similar sites bemoan how Google Search quality has precipitously declined and yearn for the Google of ~10 years ago, I think there'd be nontrivial demand for a $200/month ad-free Google with no-nonsense comprehensive results. Such a product does not exist because it would ultimately be a net loss for Google.
I'm going to guess that a big reason it doesn't exist is because a. people who claim to be willing to pay 200/mo for it won't actually open their wallets given the opportunity, and b. even for the miniscule number of people actually possible in the market to do so, they moan and groan about any perceived problem with the product to the point that it's not worth trying to capture the market. Just look at the comments in this very thread complaining about YouTube Premium and how it isn't perfect because it can't block creator inserted ads. There's no pleasing people. And that's an order of magnitude less than 200/mo.
Reminds me of vid.me, who picked up on the intense hatred towards youtube and launched a competing video host that actually got some serious traction. No ads, no subscriptions, just pure good content.
They went bankrupt in a year. Turns out internet consumers are just painfully entitled.
The integration of ads is a problem but content creators and marketers have had an adversarial relationship with SEO with Google for a long time, the old algorithm probably would not work as well as what they are providing.
It was meant as an addendum. I might have confused it with the chancery house on the other side of the road, streetview footage shows construction signs for a coworking space so I assumed it would be that.
The actual address seems to be from a law firm, not sure how good of a sign that is.
It's not unusual for UK companies to use their solicitor's address
Tangential but did not see it mentioned: Calibri must have been the Microsoft Word default at some point, at least in some parts of the world, because seeing it makes me think this is a Word document by a person that did not change the default font.
This is for a database, no? While Borzoi is a model?
> Here, we introduce Borzoi, a model that learns to predict cell-type-specific and tissue-specific RNA-seq coverage from DNA sequence.
https://www.nature.com/articles/s41588-024-02053-6
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