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One Codex (YC S14) | San Francisco (Mission) | Software + Scientist Roles | Onsite + Remote | https://www.onecodex.com

One Codex is a platform for microbial genomics. We are a technical, experienced team working on meaningful problems that range from infectious disease diagnostics to outbreak epidemiology to improving our understanding of the microbiome. We work with top researchers, medical institutions, and biotechs, and have processed samples from all seven continents (and space!). Here's what we're doing to help out with COVID-19: https://www.onecodex.com/blog/2020/03/16/covid-19-sequencing...

We're currently looking for engineers across multiple positions, including both those who are backend- and frontend-leaning. Our stack includes Python, Rust, and Javascript/Typescript (React), and we write everything from D3 visualizations to low-level bioinformatics algorithms. We are also hiring microbiologists/computational biologists.

Challenges include: (1) developing novel algorithms for analyzing complex microbial communities; (2) working with terabytes of genomic data; (3) building scientifically reproducible analyses suitable for both research and the clinic; and (4) supporting scientists and developers building on our platform with extensible APIs.

We are based in San Francisco and offer a competitive salary and meaningful above-market equity. Benefits include full medical, dental, and vision coverage, and a flexible vacation policy.

Please apply here: https://www.onecodex.com/careers/


No, sensitivity is TPs / all positives (detected TP and FN). It’s the green half of the diagram in your link. The language is very easy to get tripped up by though. :)


I think I’m getting tripped by false positive, true positive.

A test with high sensitivity will have a low false positive rate.

A test with high specificity will have a low false negative.

So having a test with high sensitivity but low specificity will result in trust in the positives, but not trust in the negatives?


For me it’s easier to think of sensitivity as being “sensitive to the true positive” without saying much about false positive or negative.

A sensitive test will catch many positive cases. It may or may not have false positives though, eg a test that’s always gives the right answer vs a test that always returns positive no matter what.

A specific test will give you few positive results when the true answer is negative. You could use it to rule something out. One test might say “patient has A or B condition”, and a second test with high specificity may then rule out A or B, leaving B or A, respectively, as the probable condition.


One Codex (YC S14) | San Francisco (Mission) | Software + Scientist Roles | Onsite + Remote | https://www.onecodex.com

One Codex is a platform for microbial genomics. We are a technical, experienced team working on meaningful problems that range from infectious disease diagnostics to outbreak epidemiology to improving our understanding of the microbiome. We work with top researchers, medical institutions, and biotechs, and have processed samples from all seven continents (and space!).

We're currently looking for engineers across multiple positions, including both those who are backend- and frontend-leaning. Our stack includes Python, Rust, and Javascript/Typescript (React), and we write everything from D3 visualizations to low-level bioinformatics algorithms. We are also hiring microbiologists/computational biologists.

Challenges include: (1) developing novel algorithms for analyzing complex microbial communities; (2) working with terabytes of genomic data; (3) building scientifically reproducible analyses suitable for both research and the clinic; and (4) supporting scientists and developers building on our platform with extensible APIs.

We are based in San Francisco and offer a competitive salary and meaningful above-market equity. Benefits include full medical, dental, and vision coverage, and a flexible vacation policy.

Please apply here: https://www.onecodex.com/careers/


One Codex (YC S14) | San Francisco (Mission) | Software + Scientist Roles | Onsite + Remote | https://www.onecodex.com

One Codex is a platform for microbial genomics. We are a technical, experienced team working on meaningful problems that range from infectious disease diagnostics to outbreak epidemiology to improving our understanding of the microbiome. We work with top researchers, medical institutions, and biotechs, and have processed samples from all seven continents (and space!).

We're currently looking for engineers across multiple positions, including both those who are backend- and frontend-leaning. Our stack includes Python, Rust, and Javascript/Typescript (React), and we write everything from D3 visualizations to low-level bioinformatics algorithms. We are also hiring microbiologists/computational biologists.

Challenges include: (1) developing novel algorithms for analyzing complex microbial communities; (2) working with terabytes of genomic data; (3) building scientifically reproducible analyses suitable for both research and the clinic; and (4) supporting scientists and developers building on our platform with extensible APIs.

We are based in San Francisco and offer a competitive salary and meaningful above-market equity. Benefits include full medical, dental, and vision coverage, and a flexible vacation policy.

Please apply here: https://careers.onecodex.com/


One Codex (YC S14) | San Francisco (Mission) | Software + Scientist Roles | Onsite + Remote | https://www.onecodex.com

One Codex is a platform for microbial genomics. We are a technical, experienced team working on meaningful problems that range from infectious disease diagnostics to outbreak epidemiology to improving our understanding of the microbiome. We work with top researchers, medical institutions, and biotechs, and have processed samples from all seven continents (and space!).

We're currently looking for engineers across multiple positions, including both those who are backend- and frontend-leaning. Our stack includes Python, Rust, and Javascript/Typescript (React), and we write everything from D3 visualizations to low-level bioinformatics algorithms. We are also hiring microbiologists/computational biologists.

Challenges include: (1) developing novel algorithms for analyzing complex microbial communities; (2) working with terabytes of genomic data; (3) building scientifically reproducible analyses suitable for both research and the clinic; and (4) supporting scientists and developers building on our platform with extensible APIs.

We are based in San Francisco and offer a competitive salary and meaningful above-market equity. Benefits include full medical, dental, and vision coverage, and a flexible vacation policy.

Please apply here: https://careers.onecodex.com/


I noticed that some past postings did not include remote options for OneCodex, and I don't see anything on the Careers page. Is this offering only open to those in (or willing to relocate to) San Francisco?


One Codex (YC S14) | San Francisco (Mission) | Software + Scientist Roles | Onsite + Remote | https://www.onecodex.com

One Codex is a platform for microbial genomics. We are a technical, experienced team working on meaningful problems that range from infectious disease diagnostics to outbreak epidemiology to improving our understanding of the microbiome. We work with top researchers, medical institutions, and biotechs, and have processed samples from all seven continents (and space!).

We're currently looking for engineers across multiple positions, including both those who are backend- and frontend-leaning. Our stack includes Python, Rust, and Javascript/Typescript (React), and we write everything from D3 visualizations to low-level bioinformatics algorithms. We are also hiring microbiologists/computational biologists.

Challenges include: (1) developing novel algorithms for analyzing complex microbial communities; (2) working with terabytes of genomic data; (3) building scientifically reproducible analyses suitable for both research and the clinic; and (4) supporting scientists and developers building on our platform with extensible APIs.

We are based in San Francisco and offer a competitive salary and meaningful above-market equity. Benefits include full medical, dental, and vision coverage, and a flexible vacation policy.

Please apply here: https://jobs.onecodex.com/


Does anybody know if (and how) this applies to spot instances? None of the language seems to exclude application to spot prices, though I realize the use-it-or-lose-it nature of these discounts has some tensions with bursty spot workflows.


This is equivalent to RI right, so won't apply to spot. Instances now have On-demand, Savings Plan and Spot pricing.


Just as with RIs, Savings Plans do not apply to spot.


The performance and track record of these engines is even more impressive when you realize that all of the design and modeling work was largely done by hand!

This is perhaps apocryphal, but I briefly worked with a guy who’d worked on the F-1 engine, and he said they’d use surplus WW2 grenades to simulate distortions/aberrations in the combustion chamber.


Gah, Polymer. Glad to hear I'm not the only one bitten by that...

(Did a single site with it, worked for a year and then for 6 months only in Safari/Firefox, and then we ported it to sit atop another Google project... ¯\_(ツ)_/¯ )


One Codex (YC S14) | San Francisco (Mission) | Software + Scientist Roles | Full-time (ONSITE) | https://www.onecodex.com

One Codex is a platform for microbial genomics. We are a technical, experienced (and profitable!) team working on meaningful problems that range from infectious disease diagnostics to outbreak epidemiology to improving our understanding of the microbiome. We work with top researchers, medical institutions, and biotechs, and have processed samples from all seven continents (and space!).

We're currently looking for engineers across multiple positions, including both those who are backend- and frontend-leaning. Our stack includes Python, Rust, and Javascript/Typescript (React), and we write everything from D3 visualizations to low-level bioinformatics algorithms. We are also hiring for a microbial genomics scientist position.

Challenges include: (1) developing novel algorithms for analyzing complex microbial communities; (2) working with terabytes of genomic data; (3) building scientifically reproducible analyses suitable for both research and the clinic; and (4) supporting scientists and developers building on our platform with extensible APIs.

We are based in San Francisco and offer a competitive salary and meaningful above-market equity. Benefits include full medical, dental, and vision coverage, a flexible vacation policy and relocation assistance if moving to the Bay Area.

Please apply here: https://jobs.onecodex.com/


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