Taken in light of the existence of the glymphatic system, a robust mechanism of clearance activated by slow wave sleep, what is more likely... misfolded protein accumulation is incidental to the loss of sleep during the course of fatal familial insomnia or loss of sleep is incidental to what is actually a disease of misfolded proteins?

Allele misassignment is another rampant issue. https://www.ncbi.nlm.nih.gov/pubmed/18154681?dopt=Abstract

I appreciate your comment, despite not relating to it very well and it seeming a bit strange to me.

I know that might come across a bit odd, but it's refreshing to actually try to understand other viewpoints and to do so inoffensively.

It sure seems like patterns of cortical activation (or something like that) could be compared to some sort of waking standard to take a very good measured guess at some point.

That's awfully late in life to be developing a foundation for morality. It seems far more likely to be extremely influenced by early upbringing.

More controversially, there may even be a genetic component too. https://www.sciencedaily.com/releases/2019/02/190225145632.h...

We are still so early in the understanding of ourselves and, by extension, society.

Interestingly, the legacy of Biosphere 2 includes the recently emerging fasting and fasting-mimicking science demonstrating some interesting healthspan promoting properties. Dr. Roy Walford of Biosphere 2 helped kick off the caloric restriction field thanks to his experiences.

Valter Longo explains that his tenure in Walford's lab as one of the preludes to some of his great work demonstrating that some of the benefits of CR are achievable by using discrete periods of fasting as opposed to long-term restriction, which has obvious challenges of practicality and undesirable effects like emaciation just to name a few.

He talks about Dr. Walford's time in biosphere 2 and how it impacted both Walford's work and, ultimately, his own.

Starts around here around 00:01:45... https://www.youtube.com/watch?v=d6PyyatqJSE&t=00h01m43s

This was based on the SELECT trial data, which means that it could just as easily be measuring the effects of a very large and prolonged dose of 400 IU of alpha-tocopherol as it is omega-3. Greater than 12x RDA.

Moreover, it's been many years since this was published. If prostate cancer-promoting effects were so plainly an obvious effect of marine omega-3 supplementation, you'd expect to have seen it abundantly replicated by now.

Maybe not, it's a very slow growing cancer, so they say.

What if it's both?

VSL#3 is one that has a lot of clinical research (search Google Scholar or PubMed). The catch is that the company producing VSL#3 no longer uses the formula that historically was used in the vast array of clinical research conducted. Whether some of the changes matter is up for debate. However, the original formulation is now sold under brand name Visbiome.

https://www.visbiome.com/blogs/news/maryland-federal-jury-un...

Some research is adopting this pattern too. A great example is Dr. Satchin Panda's clinical trial on time-restricted eating. You self-select an eating window and then document it through the app. Pretty cool stuff. mycircadianclock.org