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Peptides can have very powerful effects. Tirzepatide (Mounjaro, Zepbound) is a peptide, and it's probably the most exciting pharmaceutical in a generation.

There are also peptides that seem to have similar effects as regular exercise; a weekly injection might give you the same benefits as a daily mile run. These haven't been well studied, however, and we don't understand their safety profiles.

But the influencer set has taken these possibilities and run with them, because they're more interested in clicks and views that science and facts.


This is a preview of what's to come, but not in the way people think.

Oracle has dumped billions of dollars into AI, and planned to be the source of choice to build out AI data centers. They've taken on more debt in the past two years than many nation states.

These layoffs are entirely about cutting costs in order to manage this debt. It has nothing to do with human developers being made obsolete, or even increased developer productivity due to AI.

This is actually about investments in AI not paying dividends, and drastic cuts in personnel to keep the company solvent.


I had to check if it was April Fool's Day


Anecdotally, I haven't seen any real improvement from the AI tools I leverage. They're all good-ish at what they do, but all still lie occasionally, and all need babysitting.

I also wonder how much of the jump in early 2025 comes from cultural acceptance by devs, rather than an improvement in the tools themselves.


I think I'm coming to the same conclusion Gpt-3 to 5.3 have had real tangible but incremental improvements with quite diminishing returns.

Perhaps we won't see a phase change like improvement as we did from gpt-2 through to 3 until there is several more orders of magnitude parameters and/or training. Perhaps we will never see it again!

What is getting rapidly better is scaffolding but this seems to be more about understanding and building tools around LLMs than the LLMs themselves improving.

I'm still excited about AI but not constantly hyped to the rafters as some.


I think it depends on what you're using it for. If it is a simple kubernetes config then the model doesn't matter too much. Contract that with writing the scenario for a backtest for an algo that trades on a venue: it is not the same complexity and the basic models are terrible. I've had it tell me that it has added tests to find that they're just stubs! Opus seems to be getting there, but on more complex tasks the others are a complete waste of time.


> If it is a simple kubernetes config then the model doesn't matter too much

I guess at least this person https://www.tomshardware.com/tech-industry/artificial-intell... might disagree. I think already to know what Kubernetes even is requires quite a bit of knowledge. Using a tool that manipulate its configuration files IN PRODUCTION without risking data loss is another ball game entirely.


It’s better pre and post training + better harnessing


This is what the internet was supposed to be


I am baffled that a site called "grub street" believes anyone is going to subscribe to their newsletter after zero free articles.


I had the same thought.. more power to them I guess ¯\_(ツ)_/¯


I'm not an expert in digital footprint-hiding, but it's probably a good idea to replace / remove the SIM card as well. A factory reset will leave data laying around, just not accessible through "normal" means.


Or just buy a cheap point-and-shoot, and stick a giant SD card in it:

https://www.bestbuy.com/site/searchpage.jsp?browsedCategory=...

That's seems like an all-around better option than trying to make an old phone work like a point-and-shoot camera.


On any modern phone, your phones user partition is encrypted with a key that is itself encrypted by a key stored in the CPU. When you factory reset, what's happening is basically the key in the CPU is deleted, then re-created. At that point the data on your partition is random noise, so a new encryption key is derived and used to format the partition.

Even better, modern Android then encrypted your personal data with yet another layer based on your password/key/pattern you use to unlock your device. Many layers.

Retrieving that data would be incredibly hard even for a nation state unless the encryption used was deliberately backdoored, and even then once the device TRIM's the space (which it likely does prior to formatting) that data is gone on a hardware level.

(TL;DR Can't move the memory chip to a new device, and even if you backdoor the OS you still need the users password)


> I have a hot take that MAHA is a modern eugenics movement

The right wing in America isn't trying to improve the population, they're grifting and hoping that 1. they won't face the same consequences as their supporters, because they're rich enough to be shielded, and 2. that they're going to die before society collapses from the havoc they unleash.

This is also true of, say climate change.


There is a massive difference between requiring scientifically, medically proven vaccines that have demonstrably ended terrible diseases that once absolutely ravaged our population, and requiring anybody to follow the "health recommendations" of someone who's only credentials are surname and ability to brown-nose.


The anti-vax movement was built entirely on a foundation of fraud [1]. That leaves us with two main categories of people who are anti-vaccination:

1. People who are ignorant 2. People who are using anti-vax propaganda for some kind of gain

In the US, category two have gone all-in on using category one to gain political power. The "health official" in this post is clearly in category two, and might be in category one as well, but he is absolutely deserving of invectives.

[1] https://en.wikipedia.org/wiki/Andrew_Wakefield


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