Ok, I see my misunderstanding. Gene driving takes both genetic engineering, like the process you pointed to initially, and it would require a catch-and-(selective)-release approach that works on guiding sexual reproduction (sorta like domestication, not gene therapy). (Aside: This reminds me of the TED talk https://www.ted.com/talks/paul_ewald_asks_can_we_domesticate... )

It makes a lot more sense to me when looking at it on a population level, rather than genetic. Emphasizing gene-level enhancements seems to inspire a "one-and-done approach" view, when as in the paper you added, its authors note several open questions they want to answer later (like these two):

* How can large numbers of high-quality modified insects be reared economically? In this context, how can insect quality be assessed?

* How should potential risks relating to the long-term instability/evolution of self-sustaining genetic elements be investigated, assessed and mitigated?

It seems, they have eyes bigger than their stomachs.

I will keep my eyes open to new tools from a wide range of fields. Influencing mosquito populations' genetics seems worthwhile, long-term. To get behind it, I simply want to see some practical approaches, like some phenotypic sorting tools, and some studies showing good mosquito DNA diffs. As related to this article, how/when could this work at scale in all parts of Earth mentioned here?

Excellent. In regards how to best target the mosquitoes using this system this is still an open question, but it is now an engineering and political problem, not science problem.