FWIW, it's worth considering we (graphistry) work at the edge of what is possible in browsers. We hook up GPUs in the client to GPUs in the cloud for an unprecedently rich visual analytics experience. Think building Netflix, Photoshop, or Google maps for data. If mostly react and falcor, with only sprinkling finegrained rx, is how we handled the perf and composition mess, I'm pretty sure simpler apps can do even less than us.
Looks interesting... You're doing statistical visualisations using WebGL and GPU acceleration? If that's right, would you mind sharing a little of how you're setting up your overall architecture?
The web projects I'm working on are in a slightly different field. We also seem to be pushing the practical limits of browser-hosted GUIs with some of our interactive visualisations, but they tend to use SVG. WebGL is one of the technologies that is definitely on my "could be interesting/useful" radar, but I haven't tried to do anything serious with it yet, so I'm wondering how different a real-world-scale project would be.