Good to hear, what sound card are you using? Also what plug-in formats? If more than stereo in/out number of connections, do you have access to them all within Reaper?

Most of my plugins are VST but many are home-brewed and only just about stable on my windows machine.

I use a Lexcion Alpha + Line 6 Helix. A total of 10in/10out, all accessible in Reaper.

I mostly use Reaper stock plugins but there are a number of vst3's compiled for linux and I've written a few of my own using vst3 which work well.

You could use a plugin host connected up with jack for others but I haven't tried that much.