I don't know whether this is the best set of extensions, but I'm personally using a mix of

- uBlock Origin

- Facebook Container

- Decentraleyes, ClearURLs

- HTTPS Everywhere

- Privacy Badger.

- Redirect AMP to HTML

- Terms of Service; Didn’t Read

- Smart Referer

- User-Agent Switcher

Next to that I'm using Bitwarden and Floccus (Nextcloud Bookmarks) for self-hosted decentralised password and bookmarks sync.