The performance lacks somewhat and the debugging tools are not as mature as JVM's. But the libraries, frameworks, and overall development productivity are great.
Some of the newer ASGI frameworks are actually pretty good performance-wise. I haven't touched Node.js in years and recently needed a backend for an iOS project with a lot of geoJSON processing, used FastAPI and found it excellent. While Python is far from perfect it opens you up to a diverse ecosystem from AI/ML/Geo/science communities.
The performance lacks somewhat and the debugging tools are not as mature as JVM's. But the libraries, frameworks, and overall development productivity are great.