Usually chaperones just accelerate the process, but some proteins requires chaperones to fold properly. chaperones. some of them prevent or correct damage caused by manifolding.
The protein folding problem (as tested by the CASP competition, and "won" by DeepMind here) does not include proteins that require chaperones. It covers spontaneous reversible folders like ribonuclease A.
Usually chaperones just accelerate the process, but some proteins requires chaperones to fold properly. chaperones. some of them prevent or correct damage caused by manifolding.