Guinea pig farms selectively breading for ever smaller pigs will replace nanometer race in chip fabs. Neurons per mm^3 and the ratio of brain to overall body mass will be the new benchmarks. Heat dissipation will still be an issue, with the added complications of efficient sustenance delivery and excrement disposal. Cutting edge research will be done on immunology to prevent guinea array viruses.

There's definitely enough material here for a Douglas Adams style spoof on the traditional cyberpunk novel.