My impression is that even though the article refers to gamers, these players are unlike most gamers in that they may have extensive knowledge of organic chemistry. The article may be over-simplifying the amount of expertise required to come up with the solution.
Nope you don't need knowledge in organic chemistry. You basically run through a tutorial on the "rules" and then you fiddle with 3D models trying to get them as packed together as possible to achieve a % which increases your score.
