I feel like autoimmune, endocrine, and GI issues, and various combinations of those are the biggest frustration to people, along with complicated surgeries/replacements that we just haven't figured out yet. But those first three are horribly complicated and interrelated systems whose disorders affect probably close to a third of the population, maybe half. Just autoimmune thyroid issues affect about a fifth of women. Not to mention all thyroid issues, autoimmune diabetes, other diabetes, chrons, ibs, fibro myalgia, maybe long covid, etc. You are right to point out that many suffering from those conditions wouldn't even be alive without modern treatments and that we don't notice all that modern medicine can solve. But we also need to acknowledge there are many people for whom we dont have answers yet, and we are using evidence based medicine to say that because we don't have studies yet, there is nothing to be tried. I also think diet and lifestyle changes get undersuggested due to ebm. No one seems as eager to fund a study that tests a diet or activity to treat a condition as they are to fund investigation into a new drug, surgery, or diagnostic equipment.