PGO on a conventional executable with accumulated profiling data is likely to be more performant. JITs also have a problem because they must transmute RW data pages into RO code pages to satisfy NX. PGO enables longer-term analysis that effectively supersedes JIT. JITs are nice in theory, but don't tend to save profiling data to drive optimizations in performance-critical sections that matter.

Might try LuaToCee and then apply PGO iteratively.