I feel we will eventually outpace our own means of destruction. The next big step is getting self-sustaining colonies off Earth, which will do wonders for our ability to survive as a species. The biggest threat is perhaps nuclear weapons and climate change, in my opinion.
I actually feel like the biggest threat we face is a collapse of world order and another world war, even conventional coupled with a degradation of humanism. These lead to a global decay of basically everything, including our ability to outpace our own means of destruction and an entire inability to address climate change. The global environment becoming increasing toxic to our age’s life, including humans is I think ultimately the end of our line.