Prezi lost me a PhD co-advisor, this person only liked traditional slide formats. In retrospect, this was a good thing to not have this person oy board. I used it pretty close to traditional slides, but they could not be made happy unless it was powerpoint... Separately, I did have a lot of fun making a Prezi to explain how GPUs worked for another class, which went over swimmingly for a different audience.

I ended up using reveal.js for my defense slides because the 2D slide grid allows you to go deep on a subject and keep the main flow clean.