That doesn't list IE as a supported platform at all (not even the current IE9), so while you should be OK (if IE is now as close to compliant as MS claim it should just work) if you find problems in IE you might be on your own when it comes to researching and fixing them.
See http://zeptojs.com/#platforms - specifically "we may add support for Internet Explorer 10 ... depending ..." and the lack of any mention of IE before 10.
See http://zeptojs.com/#platforms - specifically "we may add support for Internet Explorer 10 ... depending ..." and the lack of any mention of IE before 10.