I use a NUC as a daily driver. The problem with NUCs is that cooling is suboptimal, the fan is small and thus noisy. It can be fixed with a third-party case, but that's at least €60-100 more for a much slower machine. Plus, you may void the guarantee by transplanting the motherboard.
It’s a shame that ASUS cancelled the NUC Extreme line. I know it’s quite a bit bigger than other NUCs. But the 13 Extreme had expandability, good cooling, and fast CPU options.