I think employers, already prone to looking askance at resume gaps, might be particularly put off by that (no counter example of long commitment, no way to brush it off as a better offer or need to move). I personally wouldn't risk it until I had four or five years at one company but others may have more confidence.

You might be able to get extended unpaid time off without leaving. My team has an unofficial policy that you can take up to about a month unpaid (not every year).