Yes, exactly, a workspace for each one of those. A snippet from my Aerospace config:

  [[on-window-detected]]
  if.app-id = 'com.microsoft.teams2'
  run = 'move-node-to-workspace 7'
  
  [[on-window-detected]]
  if.app-id = 'com.hnc.Discord'
  run = 'move-node-to-workspace 8'
  
  [[on-window-detected]]
  if.app-id = 'com.spotify.client'
  run = 'move-node-to-workspace 9'

They're 'persisted' in the sense that when I open them, they automatically open in their relevant workspace. You can also make them auto-start, so when your system boots up, they'll be in the right place.