THe big challenge is separating the good from the bad commercial interests. It's not a challenge because differentiating the good from the harmful is difficult, but because bad actor industries also make A LOT of money that buys a lot of political power and also employ a lot of people, so removing them from economy would have negative economic and political consequences.

Basically it's like a dead man's switch in a mutually assured destruction weapon.

Killing the tobacco industry for example would have incredibly positive economic consequences, despite the job loss.

Yeah but both tobacco industry employees and smokers vote. If they make up a large enough voter base, then this is political suicide in any democracy.

Hence how it took until 2019 to ban indoor smoking in my EU country, even though it was known for a long time it's a public health issue.