We see risk reduction for heart attack and stroke for people on GLP-1s even without weight loss, which belies the idea that the protection only comes from losing weight.
Edit:
In fact, from the study -
BMI went from 35.86 (Continued) to 34.57 (Discontinued) to 35.48 (Interrupted),
Heart failure percentage was 11.57% for continued use, 12.73% for discontinued, 11.92% for interrupted
NICM went 3.10% for continued, 3.36% for discontinued, 3.31% for interrupted
BMI was higher for the continuing users and they still had lower heart failure and NICM rates than the discontinued and interrupted groups. (Also a bunch of other things including stroke and heart attack but I didn't want to write all of these out)
Have you got a link to the study those figures are actually from? I'm not saying their wrong but I would like to read and understand them for myself before I change my mind.
> BMI went from 35.86 (Continued) to 34.57 (Discontinued) to 35.48 (Interrupted),
So, what, was 35.86 the BMI at the start, 34.57 the BMI when they stopped taking the drug, and 35.48 after some interval?
For someone of a fairly average height, say 1.86 metres (that's a little under how tall I am) a BMI of 35.86 would be 124kg which is ridiculously fat and 34.57 would be around 119.6kg so you're looking at a loss of around 4.5kg or so.
That's a good shit and a haircut, in the grand scheme of things. It's fairly normal for someone's weight to fluctuate by a kilo up or down (a range of 2kg over normal) and not utterly off the map for a range of four kilos on a day-to-day basis, especially in obese people. That's why you're not supposed to keep weighing yourself and obsessing over the weight.
Edit: In fact, from the study -
BMI went from 35.86 (Continued) to 34.57 (Discontinued) to 35.48 (Interrupted),
Heart failure percentage was 11.57% for continued use, 12.73% for discontinued, 11.92% for interrupted
NICM went 3.10% for continued, 3.36% for discontinued, 3.31% for interrupted
BMI was higher for the continuing users and they still had lower heart failure and NICM rates than the discontinued and interrupted groups. (Also a bunch of other things including stroke and heart attack but I didn't want to write all of these out)