If you register your company in WY but will be doing business in e.g. MA, you will have to pay registration fee in both jurisdictions. Doesn't sound like a saving to me.
If you mean why not register in your state, then Delaware has some tax benefits I believe. Not sure they will apply in MA though, maybe somewhere else?
Since my business is in MA it doesn't matter where my LLC is, I would have had to pay registration fee for "Foreign LLC" in MA to stay legal. That is in addition to fees I would have paid to DE. Not sure if MA is so unique, but I don't think it is.
Situations have changed in tech so I'll probably keep my LLC for a while but when things come up for renewal probably no reason to. Associated with another company and not beating bushes for big time-consuming contracts.
If you mean why not register in your state, then Delaware has some tax benefits I believe. Not sure they will apply in MA though, maybe somewhere else?