This is interesting. I am the author of Gate One (https://github.com/liftoff/GateOne) and I learned early on that Chrome doesn't let JavaScript override Ctrl-T, Ctrl-W, and Ctrl-Tab but Ctrl-O? That's silly. There's no reason why they couldn't override that.

Note: You can work around the Ctrl key override problem by opening up any web app via an "application shortcut". Menu-Tools->Create application shortcut.