I live in St. Paul (just to the east of Minneapolis, for you non-Minnesotans). I love the area, but it really is a harder environment for a startup. My buddy and I had a fun startup back in 1996. We had an OK run for about a year, but we just felt like we were living on a deserted island.

I'm married now with three kids, and if I were to start something again, I would still seriously consider relocating to Boston or San Francisco.