It works with many mailservers, on postfix it's called recipient_delimiter. It's enabled on dreamhost as + as far as I know.
The amount of spam/phishing I'm getting to me-macromedia@ and me-adobe@ is pretty amazing. Guess I was part of _that_ breach.
I'm not sure I'd go through that if I were doing it again. I've got hundreds of those emails out there, and being able to just drop some of them hasn't been the help that I would have hoped for.